ANALGESIC AND ANTI-INFLAMMATORY POTENTIAL OF THE ETHANOL EXTRACT OF LEAVES OF Laportea aestuans (L.) CHEW IN ALBINO WISTAR RATS
DOI:
https://doi.org/10.46881/ajsn.v5i0.120Keywords:
Laportea aestuans (LA), Analgesic, anti-inflammatory activities, Carrageenan, Ibuprofen, DiclofenacsodiumAbstract
In traditional medicine, Laportea aestuans (LA)is used in treatment of several ailments including pain and inflammatory conditions. This study evaluates the analgesic and anti-inflammatory potential of the ethanol extract of the leaves of LA using hot–plate induced analgesia and carrageenan–induced acute inflammatory model in Albino Wistar rats (120g-160g). The analgesic activity was assessed by oral administration of the extract doses; 50, 100 and 150 mg/kg bwt to separate groups of rats, 100 mg/kg bwt of ibuprofen (positive control) and 10 mL/kg bwt of distilled water (negative control).0.1mLof 1% carrageenan suspended in distilled water was injected intra-peritonially into the sub-plantar region of the right-hind paw of the rats to induce inflammation. Similar doses were given to test its anti-inflammatory activity but 10 mg/kg of diclofenac sodium was given as the positive control. The results obtained showed significant (p<0.05) dose -dependent difference among the groups. 150 mg/kg of the extract gave promising analgesic and anti-inflammatory effect which could be relatively compared with the control. LA reduced the activity of the enzymes supporting inflammation; a stable oedema formation was experienced at the second hour which could signify maximum level of carrageenan activity while a decline in oedema formation set in at the third hour up to the twenty-fourth hour. Phytochemical screening showed diverse secondary metabolites which could account for its wide therapeutic spectrum. These results justify the rational use of the plant in local management of pain and inflammationReferences
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