THE HORMONAL CHANGES AMONG NIGERIAN WOMEN WITH EPILEPSY
DOI:
https://doi.org/10.46881/ajsn.v10i0.173Keywords:
Hormonal Changes, Women, Epilepsy, NigeriaAbstract
This study aims to compare the sex hormones between women with epilepsy (WWE) and their agematched controls. We postulated that a difference in etiology, may be associated with an unexpected hormonal profile. A case control study carried out at the University College Hospital, Ibadan, South western, Nigeria involving seventy-five WWE and age-matched controls. Blood samples for hormonal evaluation follicle stimulating hormone (FSH), luteinizing hormone (LH), estrogen, progesterone and testosterone were taken twice from all the participants during their menstrual cycle. WWE had lower BMI (p: 0.004), cycle length (p: 0.014) and more menstrual pattern irregularities (p< 0.001.) In the pre-ovulatory phase, WWE had lower FSH levels when compared with controls, (p: 0.012). Further stratification shows a higher FSH levels among WWE on medication, (p: 0.003).In the mid-luteal phase, FSH level was lowest in WWE not on medication, WWE on medication had higher levels but lower when compared to the control group, p: 0.002. FWE had lower progesterone levels when compared with the control group, (p: 0.004) with no difference with use of AEDs. Testosterone levels were lower among those with symptomatic epilepsy, (p:0.012)WWE had lower progesterone, lower FSH and more menstrual abnormalities, compare to controls in our population.References
Amu EO, Bamidele JO (2014 ). Prevalence of menstrual disorders among adolescent girls in Osogbo, South Western Nigeria. Int J Adolesc Med Health; 26: 101-106.
Bangar S, Shastri A, El-Sayeh H, et al (2016). Women with epilepsy: clinically relevant issues. Funct Neurol, 31:127-134.
Ba-Diop A, Marin B, Druet-Cabanac M, et al. (2014). Epidemiology, causes, and treatment of epilepsy in sub-Saharan Africa. Lancet Neurol, 13:1029-1044.
Di Maio R. Neuronal mechanisms of epileptogenesis (2014). Front Cell Neurosci,, 8: 29.
El-Khayat HA, Soliman NA, Tomoum HY, et al (2008). Reproductive hormonal changes and catamenial pattern in adolescent females with epilepsy. Epilepsia, 49:16191626.
Harden CL, Pennell PB(2013) . Neuroendocrine considerations in the treatment of men and women with epilepsy,. Lancet Neurol, 12: 72-83
Harden CL, Herzog AG, Nikolov BG, et al (2006). Hormone replacement therapy in women with epilepsy: a randomized, double-blind, placebo-controlled study. Epilepsia, 47, 1447-1451.
Herzog AG, Fowler KM, Sperling MR, et al (2015). Distribution of seizures across the menstrual cycle in women with epilepsy. Epilepsia, 56: 58-62
Herzog AG (2015). Catamenial epilepsy: Update on prevalence, pathophysiology and treatment from the findings of the NIH Progesterone Treatment Trial, Seizure, 28: 18-25 Herzog AG, Coleman AE, Jacobs AR, et al (2003). Interictal EEG discharges, reproductive hormones and menstrual disorders in epilepsy. Ann Neurol,; 54:625-637.
Herzog AG(1993). A relationship between particular reproductive endocrine disorders and the laterality of epilepti form discharges in women with epilepsy. Neurology, 43, 1907–1910.
Luef G(2010). Hormonal alterations following seizures.Epilepsy Behav EB,19:131-133.
Miia Artama, J.I.T. Isojärvi, A. Auvinen (2006). Antiepileptic drug use and birth rate in patients with epilepsya population-based cohort study in Finland, Human Reproduction, 21, (9): 2290-2295,
Mukherjee J, Cardarelli RA, Cantaut-Belarif Y, et al (2017). Estradiol modulates the efficacy of synaptic inhibition by decreasing the dwell time of GABAA receptors at inhibitory synapses. Proc Natl Acad Sci U S A,114: 11763-11768.
Ogunjimi L, Yaria J, Makanjuola A, et al (2018). Sexual dysfunction among Nigerian women with epilepsy. Epilepsy Behav, 83: 108-112.
Preux P-M, Druet-Cabanac M.(2005) Epidemiology and aetiology of epilepsy in sub-Saharan Africa,
Lancet Neurol, 4:21-31Pennell PB(2009). Hormonal Aspects of Epilepsy. Neurol Clin; 27: 941.
Quigg M, Kiely JM, Shneker B, et al (2002).Interictal and postictal alterations of pulsatile secretions of luteinizing hormone in temporal lobe epilepsy in men. Ann Neurol, 51:559-566.
Reddy DS(2013). Role of hormones and neurosteroids in epileptogenesis. Front Cell Neurosci; 7:115.
Scharfman HE, MacLusky NJ.(2006) The Influence of Gonadal Hormones on Neuronal Excitability, Seizures, and Epilepsy in the Female. Epilepsia, 47, 1423-1440.
Sohrabji F, Miranda RC, Toran-Allerand CD(1995). Identification of a putative estrogen response element in the gene encoding brain-derived neurotrophic factor. Proc Natl Acad Sci U S A, 92, 11110-11114
Svalheim S, Taubøll E, Bjørnenak T, et al (2003). Do women with epilepsy have increased frequency of menstrual disturbances? Seizure; 12: 529–533
Svalheim S, Taubøll E, Luef G, et al (2009). Differential effects of levetiracetam, carbamazepine, and lamotrigine on reproductive endocrine function in adults. Epilepsy Behav EB; 16: 281-287
Scharfman HE, MacLusky NJ(2008). Estrogen–Growth Factor Interactions and Their Contributions to Neurological Disorders. Headache; 48: S77-S89.
Sato SM, Woolley CS(2016). Acute inhibition of neurosteroid estrogen synthesis suppresses status epilepticus in an animal model. eLife; 5. Epub ahead of print 15. DOI: 10.7554/eLife.12917.
Taubøll E, Sveberg L, Svalheim S (2015). Interactions between hormones and epilepsy. Seizure, 28: 3–11.
Velíšková J, De Jesus G, Kaur R, et al (2010). Females, their estrogens and seizures. Epilepsia; 51:141-144.
Velíšková J, DeSantis KA (2013). Sex and Hormonal influences on Seizures and Epilepsy. Horm Behav, 63: 267-277.
Velísková J, Velísek L, Galanopoulou AS, et al (000). Neuroprotective effects of estrogens on hippocampal cells in adult female rats after status epilepticus. Epilepsia, 241 Suppl 6, S30-35.
Verrotti A, D'Egidio C, Coppola G, et al (2009). Epilepsy, sex hormones and antiepileptic drugs in female patients. Expert Rev Neurother, 9:1803-1814.
Verrotti A, D'Egidio C, Mohn A, et al(2011). Antiepileptic drugs, sex hormones, and PCOS. Epilepsia,; 52: 199-211.
Viswanathan LG, Satishchandra P, Bhimani BC, et al (2016). Polycystic ovary syndrome in patients on antiepileptic drugs. Ann Indian Acad Neurol, 19: 339-343.
Wang Y-J, Chen K-Y, Kuo L-N, et al (2018). The association between BDNF Val66Met polymorphism and emotional symptoms after mild traumatic brain injury. BMC Med Genet; 19: 13
Younus I, Reddy DS2017. Epigenetic interventions for epileptogenesis: A new frontier for curing epilepsy. Pharmacol Ther, 177,108122
