Aurora Kinase A Expression in Nigerian Breast Cancer Patients and Correlation with Clinicopathological, Biological and Prognostic Features
DOI:
https://doi.org/10.46881/ajsn.v2i1.33Keywords:
A, genomic instability, breast cancer, Nigerian womenAbstract
Nigerian breast cancer (BC) is characterised by high incidence of triple-negative and poor prognosis. Aurora kinase A (Aurora A) regulates stem cell self-renewal and is associated with poor prognosis in BC. The aim of this study is to determine Aurora A expression and correlate it with clinicopathological, biological and prognostic features in Nigerian BC. 247 formalin-fixed paraffin embedded (FFPE) Nigerian BCs with full information on clinical history and tumour characteristics were assessed for Auroa A using tissue microarray and immunohistochemistry and correlated with pathological response and other biomarkers. Aurora A expression showed an indirect association with estrogen Receptor (ER; p= 0.002) and Progesterone Receptor (PR; p=0.001), epithelial (E)-cadherin (p=0.03) protein (p)27 (p=0.04). and direct associations with CK5/6 (p<0.001),Phosphoinositide-3-kinases (PIK3CA) (0.04), and Placenta (P)-cadherin (p<0.001),cell cycle regulators protein (p)53 (p=0.04), cyclin B1 (0.001) and cell proliferation marker, Ki-67 (p=0.01),Homologous Recombination (HR) proteins RAD51, poly (ADP-ribose) polymerase 1(PARP1) (both p<0.001), breast cancer associated gene ring domain 1(BARD1) (p=0.006),metastasis tumour antigen 1 (MTA1) (p<0.001), inhibition differentiation 4 (ID4) (p<0.001) and ubiquitin conjugate enzyme 9 ( UBC9) (p<0.001), basal-like (p<0.001) and triple-negative BC (p=0.001). Aurora A is associated with triple-negative, basal-like BC, down-regulation of HR and up-regulation of the error-prone non homologous end joining (NHEJ) DNA repair pathway. Therefore, Nigerian BC patients may benefit from involvement in a novel Aurora A targeted therapies in other to enhance management of triple –negative and basal-like BC in Nigerian patients.
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