Plasma Lipid Profile and Hepatic Transaminase Activities as indicator of Cardiovascular Disorder and Hepatocellular Damage in Type 2 Diabetes Mellitus Patients
DOI:
https://doi.org/10.46881/ajsn.v3i0.60Keywords:
Diabetes mellitus, hyperglycemia, dyslipidemia, biochemical changes, cardiovascular complicationsAbstract
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The problem of diabetes is not limited to its socioeconomic influences on the world but also the preventable complications. Management of these complications involves identifying a good predictor for early detection of such complications. This study therefore focused on determining lipid profile and transaminase activities as indicator of cardiovascular disorder and hepatocellular damage in the plasma of type 2 diabetes mellitus patients. One hundred individuals comprising fifty patients (20 males and 30 females) age range 42-70 yrs and fifty controls (32 males and 18 females) age range 40-68) were randomly selected for the study. Height and weight were measured; plasma aspartate aminotransferase (AST), alanine aminotransferase (ALT), total protein, albumin, and fasting lipid profiles (triglyceride, total cholesterol, high density lipoprotein) were determined and atherogenic (AI) and coronary risk indices (CRI) were calculated. There was no significant difference (p>0.05) in the anthropometric parameters and plasma HDL-C between the patients and controls. The plasma triglyceride, cholesterol, AST, ALT, AI and CRI levels were significantly higher (p<0.05) in the diabetic patients than the controls. Dyslipidemic changes were seen in 32 (64%) diabetic patients while 6 (12%) controls have one form of dyslipidemia or the other. The plasma total protein, albumin, and globulin levels were observed to be non-significantly (p>0.05) lower in the diabetic patients. Thus, determining plasma AST, ALT, AI, and CRI early in type 2 diabetes mellitus patients could be of importance in predicting hepatic and cardiovascular complications in type 2 diabetes mellitus.
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